https://www.liebertpub.com/doi/pdfplus/10.1089/omi.2017.0185?casa_token=fMebw6cA81AAAAAA:-GzVpELZ5GfX_ywaSxQ6qFs_AVEp8fan9Z2WZoHNsuV1sqxol9XNmBIN7Gyr-LLBb-0FsCi-PM3FzQ 2018 Biology Low