https://www.liebertpub.com/doi/pdf/10.1089/ast.2019.2043?casa_token=mCFoCKCAtzIAAAAA:Umh8Msv8AkNMeW-Pyj87gJARtcbgQ_0b5KyI4H_2TXkngx9OxacJEn2rjuJnCmI6AOKjBtOytaY3iQ Natural and cosmic Low